CRADD

Across TCGA pan-cancer cohorts, CRADD RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CRADD’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CRADD RNA is repressed in tumor relative to normal tissue. In most cancer types CRADD is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

COAD, KICH, and THCA are the cancer types where CRADD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRADD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	III,IV	−0.609	<.001	11	view →
KICH	Male	All	−0.999	<.001	9	view →
THCA	Male	III,IV	−0.608	<.001	9	view →
KIRC	Male	II,III,IV	+0.492	<.001	9	view →
UCEC	All	All	−1.146	<.001	6	view →
LUAD	Female	III,IV	−0.946	<.001	6	view →
KIRP	All	III,IV	−0.494	.006	5	view →
LIHC	Male	All	+0.461	<.001	5	view →
BLCA	Male	IV	−0.682	.016	4	view →
READ	All	All	−0.650	.018	4	view →
BRCA	Female	II,III,IV	−0.228	<.001	4	view →
STAD	All	All	−0.263	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CRADD–COAD

Open the COAD breakdown →