CRADD

Across TCGA cell cohorts, CRADD mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CRADD-associated genes across cancer lineages are DRD3, CD300H, and OR5P3. Each is linked with CRADD in more than 1 cancer types. Because this analysis shows association rather than direction, both CRADD-to-partner and partner-to-CRADD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DRD3 grouped by CRADD-low versus CRADD-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRADD→partner) and Y-score (partner→CRADD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	DRD3 →	+0.012	+4.977	<.001	.007	3	1
LARGE_INTESTINE	CD300H →	+0.052	+5.415	<.001	.004	3	1
BLOOD_Leukemia	OR5P3 →	+0.125	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM9A →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	IZUMO3 →	+0.073	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

DRD3 by CRADD expression — LARGE_INTESTINE

Explore this box plot interactively →