CRACR2B

Across TCGA patient cohorts, CRACR2B mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRACR2B-associated genes across cancer lineages are Lck, eEF2, and EGFR_pY1068. Each is linked with CRACR2B in more than 1 cancer types. Because this analysis shows association rather than direction, both CRACR2B-to-partner and partner-to-CRACR2B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by CRACR2B-low versus CRACR2B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRACR2B→partner) and Y-score (partner→CRACR2B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.287	+2.584	.002	.011	3	2
UCEC	eEF2 →	+0.450	+3.169	.006	.019	2	2
UCEC	EGFR_pY1068 →	-0.275	-2.584	.019	.011	3	1
UCEC	JNK_pT183_Y185 →	-0.214	-2.321	.006	.034	3	1
UCEC	p62 Lck ligand →	+0.373	+2.179	.013	.034	3	1
UCEC	Annexin-1 →	+0.551	+3.019	.024	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Lck by CRACR2B expression — UCEC

Explore this box plot interactively →