CRACR2B

Across TCGA pan-cancer cohorts, CRACR2B RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CRACR2B’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CRACR2B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CRACR2B is over-expressed in tumor, although a few such as LUSC and HNSC show the opposite, repressed pattern.

COAD, THCA, and LIHC are the cancer types where CRACR2B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CRACR2B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+0.967	<.001	10	view →
THCA	Male	All	+1.292	<.001	9	view →
LIHC	All	II,III,IV	+0.911	<.001	8	view →
KIRC	Male	All	+0.713	<.001	8	view →
UCEC	All	II,III,IV	+2.046	<.001	6	view →
LUSC	Male	All	−1.228	<.001	6	view →
CHOL	Male	All	+3.776	<.001	5	view →
STAD	Male	All	+1.698	<.001	4	view →
HNSC	All	II,III,IV	−0.838	.020	4	view →
KICH	Female	All	+1.068	.010	3	view →
PAAD	All	All	+1.899	.019	2	view →
PRAD	All	All	+0.997	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CRACR2B–COAD

Open the COAD breakdown →