Across TCGA patient cohorts, CRACDL mutation is significantly associated with the RNA expression of many other genes, with 5,104 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CRACDL-associated genes across cancer lineages are RNU6-905P, R3HCC1, and LMNB1. Each is linked with CRACDL in more than 2 cancer types. Because this analysis shows association rather than direction, both CRACDL-to-partner and partner-to-CRACDL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRACDL→partner) and Y-score (partner→CRACDL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RNU6-905P →	+0.417	+7.586	<.001	<.001	3	3
UCEC	R3HCC1 →	+0.446	+2.939	<.001	<.001	3	3
UCEC	LMNB1 →	+0.767	+3.098	<.001	<.001	3	3
UCEC	BRIP1 →	+0.520	+1.545	<.001	.005	3	3
UCEC	SLTM →	+0.310	+2.742	.005	.002	3	3
UCEC	KIF23 →	+0.645	+1.788	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,104 associations by consensus.

Exploration

CRACDL survival (RNA) · tumor vs normal (RNA) · all CRACDL data types