Across TCGA cell cohorts, CRACDL mutation is significantly associated with the RNA expression of many other genes, with 319 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CRACDL-associated genes across cancer lineages are OR4X2, FAM149A, and EML5. Each is linked with CRACDL in more than 1 cancer types. Because this analysis shows association rather than direction, both CRACDL-to-partner and partner-to-CRACDL results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CRACDL→partner) and Y-score (partner→CRACDL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.018	+5.369	.001	.004	3	2
LARGE_INTESTINE	FAM149A →	+1.165	+3.067	.002	.009	3	2
LARGE_INTESTINE	EML5 →	+0.759	+3.502	.008	.001	3	2
BLOOD_Leukemia	OR10G2 →	+0.764	+2.966	<.001	.005	3	2
BLOOD_Leukemia	SCGB3A2 →	+0.111	+3.185	<.001	.006	3	2
BLOOD_Leukemia	KSR2 →	+0.290	+2.884	.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 319 associations by consensus.

Exploration

CRACDL survival (RNA) · tumor vs normal (RNA) · all CRACDL data types