CR2

Across TCGA patient cohorts, CR2 mutation is significantly associated with the RNA expression of many other genes, with 6,147 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CR2-associated genes across cancer lineages are RFC5, CCNB2, and CDC25A. Each is linked with CR2 in more than 5 cancer types. Because this analysis shows association rather than direction, both CR2-to-partner and partner-to-CR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RFC5 grouped by CR2-low versus CR2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CR2→partner) and Y-score (partner→CR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RFC5 →	+0.456	+3.500	.001	.002	3	6
UCEC	CCNB2 →	+0.641	+2.555	<.001	<.001	3	6
UCEC	CDC25A →	+0.503	+1.715	<.001	.005	3	6
UCEC	CHAF1A →	+0.715	+2.758	<.001	<.001	3	6
UCEC	SPAG5 →	+0.478	+1.669	.001	<.001	3	6
UCEC	CDCA2 →	+0.715	+2.284	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,147 associations by consensus.

RFC5 by CR2 expression — COAD

Explore this box plot interactively →