CR2

Across TCGA pan-cancer cohorts, CR2 RNA is linked to patient survival in 17 of 34 cancer types, making it the most broadly survival-associated CR2 data layer compared with 10 for mutation status and 2 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher CR2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated CR2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and SKCM show a favorable association.

HNSC, SKCM, and LUAD are the cancer types where CR2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	III,IV	0.446	0.220	<.001	140	view →
SKCM	OS	Median	All	0.397	0.278	<.001	84	view →
LUAD	DFS	Tertile	All	0.737	0.582	<.001	80	view →
BRCA	DFS	Quartile	All	0.965	0.923	.003	49	view →
ACC	DFS	Tertile	All	0.837	0.479	<.001	47	view →
UVM	DFS	Quartile	III,IV	0.239	0.729	<.001	43	view →
THYM	OS	Median	All	1.000	0.750	.001	33	view →
UCS	OS	Median	II,III,IV	0.549	0.222	.017	16	view →
BLCA	OS	Median	All	0.364	0.475	.022	11	view →
ESCA	DFS	Tertile	II,III,IV	0.632	0.391	.008	8	view →
UCEC	DFS	Quartile	All	0.790	0.878	.020	6	view →
SARC	DFS	Quartile	All	0.555	0.417	.033	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 17 lineages.

CR2–HNSC (OS)

Open the HNSC breakdown →