CR2

Across TCGA patient cohorts, CR2 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CR2-associated genes across cancer lineages are eIF4E, ASNS, and MEK1. Each is linked with CR2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CR2-to-partner and partner-to-CR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CR2-low versus CR2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CR2→partner) and Y-score (partner→CR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	eIF4E →	+0.161	+3.012	.038	.018	3	4
LUSC	ASNS →	+0.327	+1.916	.044	.009	3	3
UCEC	MEK1 →	+0.317	+2.000	.002	<.001	3	3
UCEC	p62 Lck ligand →	+0.246	+1.372	.007	.022	3	3
UCEC	ATM →	-0.367	-1.321	.004	.027	3	3
COAD	Cyclin-B1 →	+0.603	+3.186	.010	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

eIF4E by CR2 expression — COAD

Explore this box plot interactively →