CR2

Across TCGA cell cohorts, CR2 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,714 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CR2-associated GO terms across cancer lineages are Negative regulation of humoral immune response mediated by circulating immunoglobulin, Regulation of humoral immune response mediated by circulating immunoglobulin, and Regulation of complement activation, classical pathway. Each is linked with CR2 in more than 9 cancer types. Because this analysis shows association rather than direction, both CR2-to-partner and partner-to-CR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of humoral immune response mediated by circulating immunoglobulin grouped by CR2-low versus CR2-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CR2→partner) and Y-score (partner→CR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Negative regulation of humoral immune response mediated by circulating immunoglobulin →	-0.341	-0.406	<.001	<.001	3	9
OVARY	Regulation of humoral immune response mediated by circulating immunoglobulin →	-0.346	-0.400	<.001	<.001	3	9
BLOOD_Myeloma	Regulation of complement activation, classical pathway →	-0.477	-2.827	<.001	<.001	2	10
BLOOD_Myeloma	Negative regulation of complement activation, classical pathway →	-0.465	-2.827	<.001	<.001	2	10
UPPER_AERODIGESTIVE_TRACT	Spermatid development →	-0.043	-0.370	<.001	.004	3	8
UPPER_AERODIGESTIVE_TRACT	Spermatid differentiation →	-0.044	-0.370	<.001	.004	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,714 associations by consensus.

Negative regulation of humoral immune response mediated by circulating immunoglobulin by CR2 expression — OVARY

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