CR2

Across TCGA cell cohorts, CR2 mutation is significantly associated with the RNA expression of many other genes, with 1,465 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CR2-associated genes across cancer lineages are CBX7, UFSP2, and ENO2. Each is linked with CR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CR2-to-partner and partner-to-CR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CBX7 grouped by CR2-low versus CR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CR2→partner) and Y-score (partner→CR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CBX7 →	+0.736	+3.257	.003	.002	3	2
LARGE_INTESTINE	UFSP2 →	+0.464	+3.321	.003	.003	3	2
LARGE_INTESTINE	ENO2 →	+1.379	+3.237	.001	.003	3	2
LARGE_INTESTINE	ULBP1 →	+1.003	+2.850	<.001	<.001	3	2
LARGE_INTESTINE	UBE3A →	+0.530	+2.158	.001	.004	3	2
LARGE_INTESTINE	CTH →	+0.968	+3.321	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,465 associations by consensus.

CBX7 by CR2 expression — LARGE_INTESTINE

Explore this box plot interactively →