CPZ

Across TCGA pan-cancer cohorts, CPZ mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of CPZ’s most consistent transcriptional readouts.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where CPZ mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types CPZ is over-expressed in tumor, although a few such as OV show the opposite, repressed pattern.

PDAC, HNSC, and OV are the cancer types where CPZ tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPZ mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
PDAC	Female	All	+0.931	<.001	10	view →
HNSC	Male	III,IV	+0.616	<.001	8	view →
OV	All	All	−0.655	.047	2	view →
COAD	Female	III,IV	+0.381	.002	2	view →
LUAD	All	All	+0.231	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

CPZ–PDAC

Open the PDAC breakdown →