CPZ

Across TCGA pan-cancer cohorts, CPZ RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated CPZ data layer compared with 9 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher CPZ RNA is associated with worse overall survival. In most high-consensus cancer types, elevated CPZ expression acts as an unfavorable survival marker, although some lineages such as UCEC and LAML show a favorable association.

KIRP, KIRC, and THCA are the cancer types where CPZ RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.848	0.975	<.001	108	view →
KIRC	DFS	Median	All	0.562	0.683	<.001	92	view →
THCA	OS	Median	All	0.953	0.996	<.001	44	view →
UCEC	DFS	Quartile	II,III,IV	0.889	0.725	.009	42	view →
OV	OS	Tertile	III,IV	0.265	0.365	.009	26	view →
LAML	DFS	Median	All	0.477	0.268	.013	26	view →
MESO	OS	Tertile	II,III,IV	0.476	0.709	.006	25	view →
LUAD	OS	Median	II,III,IV	0.837	0.656	.003	24	view →
BLCA	OS	Quartile	IV	0.748	0.436	.003	20	view →
STAD	OS	Tertile	All	0.499	0.670	.013	18	view →
LUSC	DFS	Tertile	III,IV	0.199	1.000	.004	18	view →
HNSC	DFS	Median	III,IV	0.743	0.613	.008	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

CPZ–KIRP (OS)

Open the KIRP breakdown →