CPZ

Across TCGA patient cohorts, CPZ mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. COAD shows the largest number of these associations.

The most reproducible CPZ-associated genes across cancer lineages are VHL, ATM, and Rad50. Each is linked with CPZ in more than 2 cancer types. Because this analysis shows association rather than direction, both CPZ-to-partner and partner-to-CPZ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VHL grouped by CPZ-low versus CPZ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPZ→partner) and Y-score (partner→CPZ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	VHL →	-0.775	-2.415	.002	.003	3	3
UCEC	ATM →	-0.408	-2.087	.019	.005	3	3
COAD	Rad50 →	-0.371	-2.974	.001	.035	3	2
SKCM	EGFR_pY1173 →	+0.077	+1.584	.034	.035	3	2
SKCM	Lck →	-0.311	-2.584	.017	.010	3	2
SKCM	c-Met_pY1235 →	+0.065	+2.321	.048	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

VHL by CPZ expression — UCEC

Explore this box plot interactively →