CPXCR1

Across TCGA cell cohorts, CPXCR1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible CPXCR1-associated genes across cancer lineages are OR1L3, IL3, and PRAMEF10. Each is linked with CPXCR1 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPXCR1-to-partner and partner-to-CPXCR1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by CPXCR1-low versus CPXCR1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPXCR1→partner) and Y-score (partner→CPXCR1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.022	+4.415	<.001	.007	3	2
LUNG_SCLC	IL3 →	+0.055	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF10 →	+1.180	+5.643	<.001	.002	3	1
LUNG_SCLC	PRAMEF17 →	+0.013	+5.643	<.001	.002	3	1
LUNG_SCLC	SPINK8 →	+0.513	+5.029	<.001	.006	3	1
LUNG_SCLC	PRAMEF33 →	+0.649	+5.029	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

OR1L3 by CPXCR1 expression — SKIN

Explore this box plot interactively →