CPT1C

Across TCGA patient cohorts, CPT1C mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPT1C-associated genes across cancer lineages are eIF4E, Caspase-7-cleavedD198, and FOXO3a_pS318_S321. Each is linked with CPT1C in more than 2 cancer types. Because this analysis shows association rather than direction, both CPT1C-to-partner and partner-to-CPT1C results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by CPT1C-low versus CPT1C-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPT1C→partner) and Y-score (partner→CPT1C) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.203	+3.820	.003	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.627	+2.189	.001	.001	3	3
UCEC	FOXO3a_pS318_S321 →	-0.088	-1.575	.032	.017	3	2
UCEC	INPP4B →	-0.349	-3.087	.001	<.001	3	2
UCEC	mTOR_pS2448 →	-0.169	-2.986	<.001	<.001	3	2
UCEC	Notch1 →	+0.127	+1.775	.006	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

eIF4E by CPT1C expression — UCEC

Explore this box plot interactively →