CPSF6

Across TCGA cell cohorts, CPSF6 mutation is significantly associated with the RNA expression of many other genes, with 24 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPSF6-associated genes across cancer lineages are PACRG, GHR, and RAMP3. Each is linked with CPSF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPSF6-to-partner and partner-to-CPSF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PACRG grouped by CPSF6-low versus CPSF6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF6→partner) and Y-score (partner→CPSF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PACRG →	+0.201	+3.228	<.001	.009	3	1
LARGE_INTESTINE	GHR →	+0.620	+3.517	<.001	.003	3	1
LARGE_INTESTINE	RAMP3 →	+0.126	+2.688	<.001	.008	3	1
LARGE_INTESTINE	HTR1B →	+0.061	+2.766	<.001	.005	3	1
LARGE_INTESTINE	CLDN17 →	+0.038	+3.345	.003	.001	3	1
LARGE_INTESTINE	SYN2 →	+0.830	+3.243	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PACRG by CPSF6 expression — LARGE_INTESTINE

Explore this box plot interactively →