CPSF4

Across TCGA patient cohorts, CPSF4 mutation is significantly associated with the RNA expression of many other genes, with 1,041 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPSF4-associated genes across cancer lineages are MIR3661, WDR7-OT1, and RNU6-784P. Each is linked with CPSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPSF4-to-partner and partner-to-CPSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3661 grouped by CPSF4-low versus CPSF4-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF4→partner) and Y-score (partner→CPSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR3661 →	+0.468	+5.192	<.001	.001	3	2
BRCA	WDR7-OT1 →	+0.111	+4.278	.002	.008	3	2
UCEC	RNU6-784P →	+0.231	+2.935	.001	.001	3	2
UCEC	TRAJ39 →	+0.690	+2.815	<.001	<.001	3	2
UCEC	NPLP1 →	+0.194	+2.136	.001	.004	3	2
COAD	PATE2 →	+0.190	+3.857	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,041 associations by consensus.

MIR3661 by CPSF4 expression — BRCA

Explore this box plot interactively →