CPSF4

Across TCGA pan-cancer cohorts, CPSF4 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CPSF4’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CPSF4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CPSF4 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.

COAD, HNSC, and KIRC are the cancer types where CPSF4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPSF4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	II,III,IV	+1.305	<.001	11	view →
HNSC	Male	III,IV	+1.000	<.001	11	view →
KIRC	Male	IV	+0.652	<.001	10	view →
LIHC	Female	II,III,IV	+1.423	<.001	9	view →
LUAD	All	III,IV	+0.697	<.001	9	view →
KIRP	All	All	+0.353	<.001	9	view →
LUSC	Male	All	+1.127	<.001	8	view →
STAD	Male	II,III,IV	+0.876	<.001	8	view →
BLCA	All	All	+0.640	<.001	8	view →
READ	All	II,III,IV	+0.940	<.001	7	view →
CHOL	Male	All	+1.945	<.001	5	view →
BRCA	Female	II,III,IV	−0.172	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CPSF4–COAD

Open the COAD breakdown →