CPSF4

Across TCGA patient cohorts, CPSF4 mutation is significantly associated with the total protein of many other genes, with 16 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPSF4-associated genes across cancer lineages are ATM, FOXO3a, and Lck. Each is linked with CPSF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPSF4-to-partner and partner-to-CPSF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by CPSF4-low versus CPSF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPSF4→partner) and Y-score (partner→CPSF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.437	-2.986	.038	.035	3	2
UCEC	FOXO3a →	-0.099	-2.292	.035	.034	3	1
UCEC	Lck →	+0.220	+2.584	.018	.011	3	1
UCEC	N-Ras →	-0.131	-3.687	.018	.001	3	1
UCEC	PDCD4 →	-0.587	-2.990	.007	.036	2	2
UCEC	PR →	-0.293	-3.169	.012	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

ATM by CPSF4 expression — UCEC

Explore this box plot interactively →