Across TCGA pan-cancer cohorts, CPSF1P2 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of CPSF1P2’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where CPSF1P2 RNA is repressed in tumor relative to normal tissue. In most cancer types CPSF1P2 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA and KIRC are the cancer types where CPSF1P2 tumor–normal differential expression is most reproducible.