CPS1

Across TCGA cell cohorts, CPS1 mutation is significantly associated with the mutation status of many other genes, with 6,003 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPS1-associated genes across cancer lineages are UNC79, CUX2, and ZNFX1. Each is linked with CPS1 in more than 6 cancer types. Because this analysis shows association rather than direction, both CPS1-to-partner and partner-to-CPS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UNC79 grouped by CPS1-low versus CPS1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPS1→partner) and Y-score (partner→CPS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	UNC79 →	+2.168	+2.355	.007	.007	1	7
BLOOD_Leukemia	CUX2 →	+3.360	+3.946	<.001	<.001	1	6
LARGE_INTESTINE	ZNFX1 →	+2.568	+2.568	<.001	<.001	1	6
BLOOD_Leukemia	ADGRL3 →	+2.845	+3.209	.003	.003	1	6
OVARY	PTCHD4 →	+4.930	+3.977	.001	.001	1	6
BREAST	CARD11 →	+3.442	+4.558	.003	.003	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,003 associations by consensus.

UNC79 by CPS1 expression — BLOOD_Lymphoma

Explore this box plot interactively →