CPQ

Across TCGA pan-cancer cohorts, CPQ mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated CPQ data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher CPQ mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated CPQ expression acts as an unfavorable survival marker, although some lineages such as CCRCC and PDAC show a favorable association.

UCEC, LUAD, and LSCC are the cancer types where CPQ mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	III,IV	0.286	1.000	.009	24	view →
LUAD	DFS	Median	II,III,IV	0.695	0.961	.006	13	view →
LSCC	OS	Median	All	0.767	1.000	.015	10	view →
CCRCC	DFS	Tertile	III,IV	0.766	0.291	.020	8	view →
GBM	DFS	Median	All	0.215	0.425	.021	4	view →
PDAC	DFS	Median	All	0.469	0.349	.043	2	view →
HNSC	DFS	Tertile	III,IV	0.871	0.667	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

CPQ–UCEC (OS)

Open the UCEC breakdown →