CPQ

Across TCGA pan-cancer cohorts, CPQ RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of CPQ’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CPQ RNA is repressed in tumor relative to normal tissue. In most cancer types CPQ is over-expressed in tumor, although a few such as THCA and KIRP show the opposite, repressed pattern.

THCA, LIHC, and KIRP are the cancer types where CPQ tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPQ RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−2.344	<.001	11	view →
LIHC	Male	All	+1.554	<.001	9	view →
KIRP	All	III,IV	−1.315	<.001	9	view →
LUAD	Male	II,III,IV	−1.002	<.001	9	view →
COAD	Female	II,III,IV	−0.974	<.001	9	view →
BLCA	Male	III,IV	−2.247	<.001	8	view →
LUSC	Female	All	−1.042	<.001	8	view →
UCEC	All	III,IV	−2.364	<.001	6	view →
BRCA	Female	II,III,IV	−0.743	<.001	6	view →
HNSC	Female	III,IV	+1.175	.018	4	view →
READ	Female	All	−2.138	.002	2	view →
PRAD	All	All	−0.642	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

CPQ–THCA

Open the THCA breakdown →