CPQ

Across TCGA patient cohorts, CPQ protein abundance is significantly associated with the RNA expression of many other genes, with 13,379 significant associations in total. GBM shows the largest number of these associations.

The most reproducible CPQ-associated genes across cancer lineages are NALCN, C7, and CDCA5. Each is linked with CPQ in more than 7 cancer types. Because this analysis shows association rather than direction, both CPQ-to-partner and partner-to-CPQ results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CPQ versus NALCN in UCEC, with a Pearson correlation of 0.38.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPQ→partner) and Y-score (partner→CPQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NALCN →	+0.717	+0.501	<.001	<.001	3	8
UCEC	C7 →	+2.045	+0.624	<.001	<.001	3	8
UCEC	CDCA5 →	-1.168	-0.605	<.001	<.001	3	8
UCEC	ABCA6 →	+0.957	+0.546	<.001	<.001	3	8
UCEC	CDC25A →	-0.926	-0.512	<.001	.001	3	8
UCEC	LAMA2 →	+1.402	+0.496	<.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,379 associations by consensus.

CPQ vs NALCN — UCEC

Explore this scatter interactively →