CPQ

Across TCGA patient cohorts, CPQ mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPQ-associated genes across cancer lineages are mTOR_pS2448, PDCD4, and C-Raf. Each is linked with CPQ in more than 1 cancer types. Because this analysis shows association rather than direction, both CPQ-to-partner and partner-to-CPQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by CPQ-low versus CPQ-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPQ→partner) and Y-score (partner→CPQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.152	-1.980	.007	.030	3	2
UCEC	PDCD4 →	-0.716	-3.896	<.001	<.001	3	2
UCEC	C-Raf →	+0.130	+2.584	.018	.010	3	2
UCEC	A-Raf_pS299 →	-0.108	-2.321	.018	.034	3	1
UCEC	ERK2 →	+0.195	+2.087	.008	.005	3	1
UCEC	GATA6 →	-0.138	-1.577	.022	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

mTOR_pS2448 by CPQ expression — UCEC

Explore this box plot interactively →