CPQ

Across TCGA cell cohorts, CPQ mutation is significantly associated with the RNA expression of many other genes, with 201 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPQ-associated genes across cancer lineages are FGF6, PTH, and OR4D11. Each is linked with CPQ in more than 1 cancer types. Because this analysis shows association rather than direction, both CPQ-to-partner and partner-to-CPQ results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FGF6 grouped by CPQ-low versus CPQ-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPQ→partner) and Y-score (partner→CPQ) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FGF6 →	+0.225	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	PTH →	+0.020	+4.887	.005	.009	3	1
LUNG_NSCLC_LUAD	OR4D11 →	+0.023	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	C7orf77 →	+0.034	+5.662	.001	.002	3	1
SKIN	MMP26 →	+0.026	+6.022	<.001	.001	3	1
LARGE_INTESTINE	JOSD1 →	+0.671	+3.212	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 201 associations by consensus.

FGF6 by CPQ expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →