CPOX

Across TCGA patient cohorts, CPOX protein abundance is significantly associated with the RNA expression of many other genes, with 10,840 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible CPOX-associated genes across cancer lineages are TFG, NSUN3, and NAA50. Each is linked with CPOX in more than 5 cancer types. Because this analysis shows association rather than direction, both CPOX-to-partner and partner-to-CPOX results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, CPOX versus TFG in LSCC, with a Pearson correlation of 0.54.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPOX→partner) and Y-score (partner→CPOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TFG →	+0.480	+0.321	<.001	<.001	3	6
LSCC	NSUN3 →	+0.576	+0.344	<.001	<.001	3	5
LSCC	NAA50 →	+0.419	+0.297	<.001	<.001	3	5
COAD	USF3 →	+0.604	+0.271	<.001	<.001	3	5
LSCC	RAB7A →	+0.416	+0.415	<.001	<.001	3	5
LSCC	ATG3 →	+0.473	+0.503	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,840 associations by consensus.

CPOX vs TFG — LSCC

Explore this scatter interactively →