CPOX

Across TCGA cell cohorts, CPOX RNA expression is significantly associated with the go_rna of many other GO terms, with 4,984 significant associations in total. BONE shows the largest number of these associations.

The most reproducible CPOX-associated GO terms across cancer lineages are Protoporphyrinogen IX biosynthetic process, Protoporphyrinogen IX metabolic process, and Heme B biosynthetic process. Each is linked with CPOX in more than 12 cancer types. Because this analysis shows association rather than direction, both CPOX-to-partner and partner-to-CPOX results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protoporphyrinogen IX biosynthetic process grouped by CPOX-low versus CPOX-high in BLOOD_Leukemia.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CPOX→partner) and Y-score (partner→CPOX) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	Protoporphyrinogen IX biosynthetic process →	+0.127	+0.732	<.001	<.001	3	13
BLOOD_Leukemia	Protoporphyrinogen IX metabolic process →	+0.148	+0.851	<.001	<.001	3	11
BLOOD_Leukemia	Heme B biosynthetic process →	+0.148	+0.851	<.001	<.001	3	11
BLOOD_Myeloma	Heme A biosynthetic process →	+0.115	+0.951	<.001	<.001	3	10
LARGE_INTESTINE	Positive regulation of mitotic cytokinesis →	+0.124	+0.782	<.001	.006	3	10
BONE	Protein import into peroxisome membrane →	+0.099	+0.798	.004	.007	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,984 associations by consensus.

Protoporphyrinogen IX biosynthetic process by CPOX expression — BLOOD_Leukemia

Explore this box plot interactively →