CPNE9

Across TCGA patient cohorts, CPNE9 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPNE9-associated genes across cancer lineages are S6_pS240_S244, 4E-BP1_pT70, and Rab25. Each is linked with CPNE9 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPNE9-to-partner and partner-to-CPNE9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, S6_pS240_S244 grouped by CPNE9-low versus CPNE9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE9→partner) and Y-score (partner→CPNE9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	S6_pS240_S244 →	+0.674	+2.321	.001	.035	3	2
SKCM	4E-BP1_pT70 →	+0.177	+2.339	.049	.019	3	2
UCEC	Rab25 →	-0.402	-2.459	.003	.019	3	2
UCEC	ASNS →	+0.452	+2.999	.002	.035	3	2
SKCM	PEA-15_pS116 →	+0.372	+2.321	.011	.035	3	1
SKCM	YB-1_pS102 →	+0.187	+3.459	.028	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

S6_pS240_S244 by CPNE9 expression — SKCM

Explore this box plot interactively →