CPNE9

Across TCGA cell cohorts, CPNE9 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,484 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CPNE9-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Endosomal lumen acidification, and Mitochondrial calcium ion transmembrane transport. Each is linked with CPNE9 in more than 5 cancer types. Because this analysis shows association rather than direction, both CPNE9-to-partner and partner-to-CPNE9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by CPNE9-low versus CPNE9-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE9→partner) and Y-score (partner→CPNE9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.072	+0.299	<.001	.003	3	6
CNS	Endosomal lumen acidification →	+0.083	+0.103	.001	.004	3	5
BLOOD_Leukemia	Mitochondrial calcium ion transmembrane transport →	+0.063	+0.352	.006	.002	3	5
LIVER	Blood coagulation, intrinsic pathway →	-0.400	-0.150	.001	.003	3	4
SOFT_TISSUE	Positive regulation of eating behavior →	-0.920	-0.085	.001	.001	3	4
SOFT_TISSUE	Regulation of synapse structural plasticity →	+0.767	+0.101	.007	.002	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,484 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by CPNE9 expression — LUNG_SCLC

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