CPNE7

Across TCGA patient cohorts, CPNE7 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPNE7-associated genes across cancer lineages are eEF2, Notch1, and TFRC. Each is linked with CPNE7 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPNE7-to-partner and partner-to-CPNE7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by CPNE7-low versus CPNE7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE7→partner) and Y-score (partner→CPNE7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.345	+1.700	.022	.044	3	2
UCEC	Notch1 →	+0.147	+1.887	.013	.029	3	2
UCEC	TFRC →	+0.516	+2.321	.022	.033	3	2
UCEC	c-Kit →	-0.207	-2.439	.036	.019	3	2
UCEC	EGFR_pY1068 →	-0.254	-2.906	.017	.001	3	1
UCEC	ERK2 →	+0.271	+2.584	<.001	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

eEF2 by CPNE7 expression — UCEC

Explore this box plot interactively →