CPNE7

Across TCGA pan-cancer cohorts, CPNE7 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CPNE7’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where CPNE7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CPNE7 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, KIRP, and LUAD are the cancer types where CPNE7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPNE7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+5.038	<.001	12	view →
KIRP	All	IV	+2.517	<.001	11	view →
LUAD	Female	All	+1.591	<.001	10	view →
STAD	Male	II,III,IV	+1.598	<.001	8	view →
LIHC	Male	II,III,IV	+1.094	<.001	8	view →
HNSC	Male	III,IV	+1.000	<.001	8	view →
KIRC	Male	All	+0.601	<.001	8	view →
BRCA	All	III,IV	+1.414	<.001	6	view →
READ	Female	All	+3.999	<.001	5	view →
LUSC	Male	All	+1.064	<.001	5	view →
CHOL	All	All	+3.720	<.001	3	view →
THCA	All	II,III,IV	−0.352	.010	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CPNE7–COAD

Open the COAD breakdown →