CPNE6

Across TCGA patient cohorts, CPNE6 mutation is significantly associated with the RNA expression of many other genes, with 1,445 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPNE6-associated genes across cancer lineages are REEP4, MIR548AW, and RNU6-432P. Each is linked with CPNE6 in more than 2 cancer types. Because this analysis shows association rather than direction, both CPNE6-to-partner and partner-to-CPNE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, REEP4 grouped by CPNE6-low versus CPNE6-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE6→partner) and Y-score (partner→CPNE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	REEP4 →	+0.454	+3.182	.002	.009	3	3
LUAD	MIR548AW →	+0.141	+4.108	<.001	.007	3	3
KIRP	RNU6-432P →	+0.509	+5.645	<.001	<.001	3	2
KIRP	RNA5SP53 →	+0.452	+4.890	<.001	.002	3	2
KIRP	MRPL49P1 →	+0.084	+4.497	<.001	.009	3	2
KIRP	RSL24D1P3 →	+0.123	+4.661	.009	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,445 associations by consensus.

REEP4 by CPNE6 expression — SKCM

Explore this box plot interactively →