CPNE6

Across TCGA pan-cancer cohorts, CPNE6 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CPNE6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where CPNE6 RNA is repressed in tumor relative to normal tissue. In most cancer types CPNE6 is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and BLCA are the cancer types where CPNE6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPNE6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−1.264	<.001	11	view →
KIRP	All	III,IV	−1.864	<.001	9	view →
BLCA	Male	IV	−1.339	<.001	8	view →
STAD	All	All	−0.633	<.001	8	view →
THCA	Male	All	−0.180	<.001	7	view →
KICH	All	All	−1.084	<.001	6	view →
UCEC	All	III,IV	−0.468	.004	4	view →
CHOL	All	II,III,IV	−0.080	.007	3	view →
PRAD	All	All	−1.339	<.001	2	view →
COAD	Male	II,III,IV	−0.406	.030	2	view →
READ	All	III,IV	−0.365	.024	2	view →
LIHC	Female	All	−0.296	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CPNE6–KIRC

Open the KIRC breakdown →