CPNE6

Across TCGA cell cohorts, CPNE6 RNA expression is significantly associated with the go_rna of many other GO terms, with 843 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible CPNE6-associated GO terms across cancer lineages are DNA repair-dependent chromatin remodeling, Cellular response to acidic pH, and Positive regulation of calcium ion transport. Each is linked with CPNE6 in more than 5 cancer types. Because this analysis shows association rather than direction, both CPNE6-to-partner and partner-to-CPNE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA repair-dependent chromatin remodeling grouped by CPNE6-low versus CPNE6-high in LUNG_NSCLC_LUAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE6→partner) and Y-score (partner→CPNE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DNA repair-dependent chromatin remodeling →	+0.061	+0.050	.001	.003	3	6
BLOOD_Lymphoma	Cellular response to acidic pH →	-0.091	-0.205	<.001	.006	3	5
CNS	Positive regulation of calcium ion transport →	-0.070	-0.101	<.001	.002	3	4
CNS	Granzyme-mediated apoptotic signaling pathway →	+0.053	+0.127	<.001	.009	3	4
SOFT_TISSUE	Negative regulation of proteolysis →	-0.079	-0.054	.006	.003	3	4
BLOOD_Leukemia	Negative regulation of endothelial cell proliferation →	-0.068	-0.066	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 843 associations by consensus.

DNA repair-dependent chromatin remodeling by CPNE6 expression — LUNG_NSCLC_LUAD

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