CPNE6

Across TCGA cell cohorts, CPNE6 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPNE6-associated genes across cancer lineages are OR52H1, MT4, and KRTAP4-4. Each is linked with CPNE6 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPNE6-to-partner and partner-to-CPNE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR52H1 grouped by CPNE6-low versus CPNE6-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE6→partner) and Y-score (partner→CPNE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR52H1 →	+0.017	+2.347	<.001	.007	3	2
CNS	MT4 →	+0.240	+5.321	<.001	.005	3	1
CNS	KRTAP4-4 →	+0.026	+5.754	<.001	.002	3	1
SKIN	PSKH2 →	+0.033	+4.217	<.001	.001	3	1
SKIN	IFNK →	+0.091	+4.510	<.001	.001	3	1
SKIN	TGM6 →	+0.039	+3.930	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

OR52H1 by CPNE6 expression — LARGE_INTESTINE

Explore this box plot interactively →