CPNE6

Across TCGA cell cohorts, CPNE6 mutation is significantly associated with the mutation status of many other genes, with 2,784 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPNE6-associated genes across cancer lineages are DAAM1, SLC4A8, and MAP2K4. Each is linked with CPNE6 in more than 3 cancer types. Because this analysis shows association rather than direction, both CPNE6-to-partner and partner-to-CPNE6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DAAM1 grouped by CPNE6-low versus CPNE6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE6→partner) and Y-score (partner→CPNE6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	DAAM1 →	+4.339	+4.339	.009	.009	1	4
BLOOD_Leukemia	SLC4A8 →	+3.063	+3.498	.006	.006	1	3
LARGE_INTESTINE	MAP2K4 →	+3.217	+3.217	<.001	<.001	1	3
SKIN	PKP1 →	+3.532	+3.736	<.001	<.001	1	3
LUNG_NSCLC_LUAD	IGDCC4 →	+3.339	+4.662	.003	.003	1	3
LUNG_NSCLC_LUAD	TBX6 →	+4.339	+4.339	.009	.009	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,784 associations by consensus.

DAAM1 by CPNE6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →