CPNE3

Across TCGA patient cohorts, CPNE3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPNE3-associated genes across cancer lineages are EGFR_pY1068, FoxM1, and G6PD. Each is linked with CPNE3 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPNE3-to-partner and partner-to-CPNE3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by CPNE3-low versus CPNE3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPNE3→partner) and Y-score (partner→CPNE3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.240	-1.700	.006	.040	3	1
UCEC	FoxM1 →	+0.214	+1.662	.019	.011	3	1
UCEC	G6PD →	-0.234	-2.571	.040	.010	3	1
UCEC	IGFBP2 →	-0.552	-2.321	.016	.033	3	1
UCEC	JNK2 →	+0.235	+1.710	<.001	.025	3	1
UCEC	Ku80 →	+0.252	+3.472	.002	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

EGFR_pY1068 by CPNE3 expression — UCEC

Explore this box plot interactively →