CPNE3

Across TCGA pan-cancer cohorts, CPNE3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of CPNE3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where CPNE3 RNA is repressed in tumor relative to normal tissue. In most cancer types CPNE3 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, LIHC, and BRCA are the cancer types where CPNE3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPNE3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.241	<.001	11	view →
LIHC	Male	All	+1.128	<.001	7	view →
BRCA	All	II,III,IV	+0.592	<.001	6	view →
CHOL	All	All	+1.297	<.001	5	view →
COAD	Male	All	+0.364	.009	5	view →
KIRC	Male	All	−0.282	.007	5	view →
KICH	All	All	−0.652	.002	4	view →
HNSC	Female	III,IV	+0.891	.015	3	view →
PAAD	Male	All	+0.574	.049	2	view →
KIRP	Male	All	−0.561	.001	2	view →
KIRP	Female	II,III,IV	+0.478	.046	2	view →
UCEC	All	All	−0.456	.017	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

CPNE3–THCA

Open the THCA breakdown →