CPN2

Across TCGA patient cohorts, CPN2 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPN2-associated genes across cancer lineages are MEK1, Caspase-8, and Cyclin-E2. Each is linked with CPN2 in more than 1 cancer types. Because this analysis shows association rather than direction, both CPN2-to-partner and partner-to-CPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by CPN2-low versus CPN2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPN2→partner) and Y-score (partner→CPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.457	+3.906	.001	<.001	3	2
UCEC	Caspase-8 →	-0.283	-3.087	.005	<.001	3	2
UCEC	Cyclin-E2 →	+0.261	+2.710	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.102	-3.432	.011	.005	3	1
UCEC	EGFR_pY1068 →	-0.237	-3.087	.019	<.001	3	1
UCEC	eIF4E →	+0.171	+3.087	.044	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

MEK1 by CPN2 expression — UCEC

Explore this box plot interactively →