CPN2

Across TCGA pan-cancer cohorts, CPN2 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of CPN2’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CPN2 RNA is repressed in tumor relative to normal tissue. In most cancer types CPN2 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and HNSC are the cancer types where CPN2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPN2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	All	II,III,IV	−3.835	<.001	11	view →
KICH	Male	II,III,IV	−2.733	<.001	8	view →
HNSC	All	All	+0.168	<.001	8	view →
KIRC	Male	All	−2.207	<.001	6	view →
BRCA	Female	II,III,IV	+0.280	<.001	6	view →
CHOL	Female	All	−7.966	<.001	5	view →
LUAD	All	All	+0.136	.001	5	view →
LIHC	All	All	−0.865	.001	4	view →
LUSC	All	All	+0.157	<.001	4	view →
ESCA	All	All	−0.157	.045	1	view →
THCA	Female	II,III,IV	−0.037	.046	1	view →
BLCA	Male	III,IV	+0.028	.042	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

CPN2–KIRP

Open the KIRP breakdown →