CPN2

Across TCGA cell cohorts, CPN2 mutation is significantly associated with the mutation status of many other genes, with 3,484 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPN2-associated genes across cancer lineages are ZNF395, OR2M3, and EFNB3. Each is linked with CPN2 in more than 3 cancer types. Because this analysis shows association rather than direction, both CPN2-to-partner and partner-to-CPN2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF395 grouped by CPN2-low versus CPN2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPN2→partner) and Y-score (partner→CPN2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ZNF395 →	+3.217	+3.217	<.001	<.001	1	4
UPPER_AERODIGESTIVE_TRACT	OR2M3 →	+5.392	+5.392	.004	.004	1	4
UPPER_AERODIGESTIVE_TRACT	EFNB3 →	+5.392	+5.392	.004	.004	1	4
SKIN	ABCA8 →	+2.593	+4.282	.002	.002	1	3
SKIN	FAM124A →	+5.053	+4.239	.007	.007	1	3
LARGE_INTESTINE	LRRC43 →	+3.632	+3.392	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,484 associations by consensus.

ZNF395 by CPN2 expression — LARGE_INTESTINE

Explore this box plot interactively →