CPM

Across TCGA patient cohorts, CPM mutation is significantly associated with the RNA expression of many other genes, with 1,862 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPM-associated genes across cancer lineages are ZNHIT3, ZFYVE19, and TMEM222. Each is linked with CPM in more than 1 cancer types. Because this analysis shows association rather than direction, both CPM-to-partner and partner-to-CPM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNHIT3 grouped by CPM-low versus CPM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPM→partner) and Y-score (partner→CPM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ZNHIT3 →	+0.482	+2.606	<.001	<.001	3	2
SKCM	ZFYVE19 →	+0.395	+2.745	.004	.003	3	2
SKCM	TMEM222 →	+0.392	+2.706	.008	.003	3	2
SKCM	SNORD114-23 →	+0.128	+5.116	<.001	.001	3	2
SKCM	TCP1P1 →	+0.174	+3.631	<.001	.002	3	2
UCEC	NDUFAF5 →	+0.338	+2.230	.002	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,862 associations by consensus.

ZNHIT3 by CPM expression — UCEC

Explore this box plot interactively →