CPM

Across TCGA pan-cancer cohorts, CPM RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of CPM’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where CPM RNA is repressed in tumor relative to normal tissue. In most cancer types CPM is over-expressed in tumor, although a few such as KICH and COAD show the opposite, repressed pattern.

KICH, COAD, and KIRC are the cancer types where CPM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	III,IV	−4.346	<.001	11	view →
COAD	Female	III,IV	−3.000	<.001	11	view →
KIRC	Female	II,III,IV	−1.160	<.001	10	view →
THCA	Male	All	+1.079	<.001	9	view →
LUSC	Female	II,III,IV	−3.414	<.001	8	view →
LUAD	Male	II,III,IV	−1.235	<.001	8	view →
BRCA	All	III,IV	−1.528	<.001	6	view →
READ	Female	All	−2.920	<.001	5	view →
STAD	All	All	+0.726	.001	4	view →
BLCA	Female	IV	+2.716	.037	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

CPM–KICH

Open the KICH breakdown →