CPM

Across TCGA patient cohorts, CPM mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible CPM-associated genes across cancer lineages are Annexin-1, GATA6, and 14-3-3_beta. Each is linked with CPM in more than 1 cancer types. Because this analysis shows association rather than direction, both CPM-to-partner and partner-to-CPM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by CPM-low versus CPM-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPM→partner) and Y-score (partner→CPM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.610	+3.341	.006	.005	3	2
SKCM	GATA6 →	+0.318	+2.822	.006	.034	3	1
UCEC	14-3-3_beta →	-0.137	-3.432	.001	.005	3	1
UCEC	EGFR →	-0.220	-3.321	.001	.010	3	1
UCEC	FoxM1 →	+0.258	+1.700	.019	.044	3	1
UCEC	ACVRL1 →	-0.158	-3.439	.006	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Annexin-1 by CPM expression — UCEC

Explore this box plot interactively →