CPM

Across TCGA cell cohorts, CPM mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible CPM-associated genes across cancer lineages are GLYATL3, MAGEB4, and STRA8. Each is linked with CPM in more than 1 cancer types. Because this analysis shows association rather than direction, both CPM-to-partner and partner-to-CPM results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GLYATL3 grouped by CPM-low versus CPM-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (CPM→partner) and Y-score (partner→CPM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GLYATL3 →	+0.014	+4.415	<.001	.007	3	1
LARGE_INTESTINE	MAGEB4 →	+0.024	+6.000	<.001	<.001	3	1
LARGE_INTESTINE	STRA8 →	+0.161	+4.415	<.001	.007	3	1
LARGE_INTESTINE	ZNF804B →	+0.016	+4.415	<.001	.007	3	1
LARGE_INTESTINE	DAZ2 →	+0.252	+4.415	<.001	.007	3	1
LARGE_INTESTINE	GPX5 →	+0.318	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GLYATL3 by CPM expression — SKIN

Explore this box plot interactively →