CPEB3

Across TCGA pan-cancer cohorts, CPEB3 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated CPEB3 data layer compared with 5 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher CPEB3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated CPEB3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and KIRC show a favorable association.

SKCM, KIRC, and HNSC are the cancer types where CPEB3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	All	0.682	0.548	<.001	109	view →
KIRC	DFS	Median	All	0.715	0.545	<.001	105	view →
HNSC	OS	Median	All	0.800	0.701	<.001	101	view →
MESO	OS	Tertile	All	0.713	0.401	<.001	95	view →
LIHC	OS	Median	All	0.775	0.627	<.001	76	view →
KIRP	DFS	Median	All	0.964	0.856	<.001	51	view →
LUAD	OS	Tertile	All	0.754	0.633	.007	48	view →
LGG	OS	Median	All	0.535	0.346	<.001	48	view →
SCLC	OS	Quartile	All	0.445	0.139	.007	37	view →
BRCA	DFS	Tertile	III,IV	0.923	0.790	.008	27	view →
SARC	DFS	Tertile	All	0.685	0.524	.012	17	view →
PRAD	DFS	Median	All	0.874	0.714	.006	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

CPEB3–SKCM (DFS)

Open the SKCM breakdown →