CPEB3

Across TCGA pan-cancer cohorts, CPEB3 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of CPEB3’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where CPEB3 RNA is repressed in tumor relative to normal tissue. In most cancer types CPEB3 is over-expressed in tumor, although a few such as HNSC and COAD show the opposite, repressed pattern.

HNSC, COAD, and KIRC are the cancer types where CPEB3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in CPEB3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	−1.450	<.001	12	view →
COAD	Female	III,IV	−1.142	<.001	12	view →
KIRC	Male	II,III,IV	−1.115	<.001	11	view →
THCA	Male	III,IV	−1.382	<.001	10	view →
BLCA	All	III,IV	−0.832	<.001	10	view →
KIRP	Male	II,III,IV	−0.958	<.001	9	view →
LIHC	Male	III,IV	−1.538	<.001	8	view →
READ	All	All	−0.974	<.001	7	view →
LUSC	All	II,III,IV	−0.783	<.001	7	view →
LUAD	Female	II,III,IV	−0.803	<.001	6	view →
BRCA	Female	All	−0.237	.009	4	view →
KICH	All	All	−0.490	.007	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

CPEB3–HNSC

Open the HNSC breakdown →