Across TCGA pan-cancer cohorts, CPEB1-AS1 RNA differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of CPEB1-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where CPEB1-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types CPEB1-AS1 is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.
KIRP, UCEC, and BRCA are the cancer types where CPEB1-AS1 tumor–normal differential expression is most reproducible.